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Summary of Qualifications
A multilingual professional and a
very quick mind with an insider's perspective and proven
leadership in higher education, science, health care and related
laws. Outstanding organizational and writing skills, with
high-impact executive presentation abilities. A demonstrated
talent to select, train and retain self-motivated goal-oriented
professionals. Well published and recipient of numerous awards
and recognitions in Medicine, Biomedical Research, Academic
Leadership and Law. Exceptional interpersonal and communication
skills with an extensive background in the following:
Biomedical Research
Legal Counsel
Nervous & Digestive Systems
Conflict Resolution
Clinical & Translational Sciences
Strategic Planning
Budget & Resources Management
Visioning & Persuasion
Curriculum Innovation & Integration
High-caliber Negotiation
Personnel Hiring, Development & Promotion
Policy, Regulations & Ethics
➢ A diverse educational and cultural background with a unique
ability to understand and manage sensitivities when
communicating and discussing with individuals and groups with
different philosophies, cultural backgrounds, perspectives,
approaches, and specific needs.
➢ Outstanding qualifications in strategic planning with
comprehensive knowledge of governance, management,
organizational development, team building and project execution:
successfully led the strategic planning effort for a twenty
million dollar Translational Research Institute and served as
its Director of Planning and co-Director of Governance.
➢ Commanding oral presentation ability with a record number of
invited speeches delivered to diverse audiences around the
world.
➢ Outstanding interpersonal and negotiation skills and
experience in dealing with conflicts, negotiations and conflict
resolution.
➢ Solid track record of cultivating productive relationships
with key decision makers and managing projects on a global basis
to achieve institutional goals.
➢ Well-respected high profile in the sciences of the nervous and
digestive systems: serving currently on a number of national and
international scientific and health advisory boards and
editorial boards, and a regularly invited speaker to scientific
symposia.
➢ High impact biomedical research in the fields of Neuroscience
and Digestive Diseases: designed, implemented and tested
validated models of disease, widely used in translational and
pre-clinical trials.
➢ Proven record of fundraising with an outstanding record of
research funding from the National Institutes of Health in the
USA, private non-governmental organizations and the
pharmaceutical industry.
➢ Legal advisor on issues including business planning,
intellectual property, conflict resolution, health care and
business law for a number of businesses, professionals and
individuals including medical practitioners, real estate
developers, immigration applicants and others.
➢ Works independently and as a team player depending on the
situation.
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Name
First:
Elie (\ā-‘lē\)
Middle:
Diab
Last:
Al-Chaer (\ash-
sha-‘er\)
Professional: Elie D. Al-Chaer, PhD, JD.
Present Academic Position and Address
Professor & Chairperson
Department of Anatomy,
Cell Biology and
Physiological Sciences
Faculty of Medicine
American University of
Beirut
Physical Address:
New York:
3 Dag Hammarskjold
Plaza, 8th Fl
Suite 2-33 New York,
NY 10017-2303
PO Box 11-0236 USA
Beirut:
DTS Biomedical
Research Bldg.
Riad El-Solh 1107 2020
Beirut, Lebanon
Electronic Address:
Homepage: http://www.alchaer.com
Labpage: http://www.uams.edu/acelab
E- mail:
ec11@aub.edu.lb
Phones: Off. +961 1 350-000 Ext. 4804
Admin. Asst. +961 1 350-000 Ext. 4800, 4801, 4750
Fax: +961 1 744-464
Name:
Elie Diab Al-Chaer
Date of birth:
April 1968
Place of birth:
Lebanon
Citizenship:
United States
Additional Biographical Data Available on Demand
Languages
English, French, and Arabic
All 3
fluently spoken, read and written
Education
After finishing High School at the “Collège des Frères, Mont La
Salle” (a Private French Catholic School) Aïn Saadé, Lebanon,
1985-1988: Undergraduate student, Department of Mathematics,
Faculty of Arts and Sciences, American University of Beirut (AUB),
New York Universities Board, Beirut, Lebanon
1989-1991: Graduate student, Department of Physiology, Faculty
of Medicine, American University of Beirut, New York
Universities Board, Beirut, Lebanon
1993-1996: Ph.D. student, Graduate School of Biomedical Sciences
(GSBS), University of Texas Medical Branch (UTMB),
Galveston, Texas, USA
1997-2002: Law Student, South Texas College of Law (STCL),
Houston, Texas, USA
Degrees
and Certificates
B.S. (May 1988) Mathematics, Faculty of Arts and Sciences,
American University of Beirut, New York Universities Board,
Beirut, Lebanon
M.S. (Aug. 1991) Physiology, Faculty of Medicine, American
University of Beirut, New York Universities Board, Beirut,
Lebanon (see CV-34)
Ph.D. (Dec. 1996) Neuroscience, Graduate School of Biomedical
Sciences, University of Texas Medical Branch, Galveston, Texas,
USA (see CV-34)
J. D. (May 2002) Doctor of Jurisprudence, South Texas College
of Law, Houston, Texas, USA
Certificate
International Policy and Foreign Affairs Course, Clinton School
of Public Service, Little Rock, Arkansas, USA (Jul. 2005)
Certificate
Leadership Institute, University of Arkansas for Medical
Sciences, Little Rock, Arkansas, USA (Jan. – Dec. 2007)
Professional Work History
2015 -
Professor and Chairperson, Department of Anatomy, Cell Biology
and Physiological Sciences, Faculty of Medicine, American
University of Beirut (AUB), Beirut, Lebanon.
2013 - 2015
Professor and Vice-Chair, Department of Anatomy, Cell Biology
and Physiological Sciences, Faculty of Medicine, American
University of Beirut (AUB), Beirut, Lebanon.
2009 - 2013
Professor with tenure, Departments of Pediatrics, Internal
Medicine (Division of Gastroenterology), Neurobiology and
Developmental Sciences, College of Medicine, University of
Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
2007 (July) - 09 Secondary appointment - Associate Professor,
Department of Internal Medicine, Division of Gastroenterology,
College of Medicine, UAMS.
2005 (Mar) - Member, Graduate School, UAMS.
2004 (Sep) - Director, Center for Pain Research, College
of Medicine, UAMS.
2004 (Sep) - 09 Associate Professor (Tenure Track),
Departments of Pediatrics, and Neurobiology and Developmental
Sciences, College of Medicine, UAMS.
1999 (Jan.) - 04 Associate member, Neuroscience Graduate
Program, University of Texas Medical Branch (UTMB), Galveston,
TX, USA.
1999 (Jan.) - 04 Associate member, Graduate School of
Biomedical Sciences, UTMB.
1998 (Feb.) - 04 Associate member, Marine Biomedical Institute
(MBI), UTMB.
1998 (Feb.) -
04 Assistant Professor
(tenure track), Departments of Internal Medicine and Anatomy and
Neurosciences; UTMB.
1997 (Jan.) Assistant member, Marine Biomedical
Institute, UTMB.
1997 (Jan.) Post-Doctoral Fellow, UTMB (Wm. D. Willis,
Supervisory Professor).
1994 - 96 Pre-Doctoral Fellow, UTMB (Wm. D. Willis,
Supervisory Professor).
1993 - 94 Graduate assistant, Graduate School of
Biomedical Sciences, UTMB.
1992 Instructor of “Biomechanics of Human
Motion” at the Department of Orthopedics and Orthotics, Faculty
of Medicine, American University of Beirut (AUB), Beirut,
Lebanon.
1992 - 93 Research Assistant, Faculty of Medicine,
AUB.
1988 - 89 Instructor of Mathematics for intermediate
classes at a private high school, Lebanon.
A.
Medical School
2015 -
Chairman, MED-II Class Teaching Committee, Faculty of Medicine,
American University of Beirut, Beirut, Lebanon.
2015 -
Member, Curriculum Committee, Faculty of Medicine, American
University of Beirut, Beirut, Lebanon.
2015 -
Member, Student Affairs Committee, Faculty of Medicine, American
University of Beirut, Beirut, Lebanon.
2014 -
Lecturer and Lead Consultant, The Ethics and Laws of Health Care
course, Medical Professionalism Program, Faculty of Medicine,
American University of Beirut, Beirut, Lebanon (Hybrid: online &
classroom).
2014 -
Lecturer and co-Coordinator, Integrated Medical Neuroscience
course, MED II, Faculty of Medicine, American University of
Beirut, Beirut, Lebanon (Fall, 11 contact weeks).
2013 -
Lecturer, Cellular and Molecular Basis of Medicine, MED I,
Faculty of Medicine, American University of Beirut, Beirut,
Lebanon (Fall, 4 contact hours).
2013 -
Lecturer on Ethics of Anatomy, Physicians - Patients and Society
course, MED I, Faculty of Medicine, American University of
Beirut, Beirut, Lebanon (Fall, 4 contact hours).
2005 -
2013 Lecturer, Neuroscience Course, MED I, College of Medicine,
University of Arkansas for Medical Sciences, Little Rock, AR,
USA. (April, 1 contact hour).
2003 - 2004 Lecturer and Laboratory teacher, Human
Neuroscience and Behavior Course, MED I, Integrated Medical
Curriculum, School of Medicine, University of Texas Medical
Branch (UTMB), Galveston, Texas, USA. (Spring Term, 50
contact hours)
2000 - 2001 Lecturer, lecture on “Visceral Pain and
Irritable Bowel Syndrome” GI and Nutrition Course, MED II,
Integrated Medical Curriculum, School of Medicine, UTMB. (Fall
Term, 2 contact hours)
1999 - 2002 Facilitator, Human Neuroscience and Behavior
Course, MED I, Integrated Medical Curriculum, School of
Medicine, UTMB. (Spring Term, 50 contact hours per year)
1999 Laboratory instructor, Human Neuroscience and
Behavior Course, MED I, Integrated Medical Curriculum, School of
Medicine, UTMB. (Spring Term, 50 contact hours)
1995 Teaching Assistant of Neuroscience, First Year
Medical School (MED I), Faculty of Medicine, UTMB.
B. Graduate School
2013 -
Lecturer, General Physiology-Cellular Mechanisms course,
Graduate Students, Faculty of Medicine, American University of
Beirut, Beirut, Lebanon (Fall, 4 contact hours).
2007 - 2013 Lecturer,
Cellular and Developmental Neuroscience, Graduate School,
University of Arkansas for Medical Sciences (UAMS), Little Rock,
AR. Two lectures: “Neuroscience of Pain: Mechanisms and Pathways
& Syndromes and Modulation” (Spring Term, 3 contact hours)
2006 - 2013 Lecturer, Graduate Neuroscience Course, Graduate
School, UAMS. One lecture: “Pain” (Fall Term, 1 contact hour)
2006 - 2013 Lecturer, Cellular and Developmental
Neuroscience, Graduate School, UAMS. Two lectures: “Release of
Neurotransmitters” and “Neurotransmitter Receptors” (Spring
Term, 3 contact hours)
I prepare the lectures and present them to
the graduate students taking the Cellular and Developmental
Neuroscience Course and the Graduate Neuroscience Course.
2000 - 2004 Course Director and Lecturer, Core Pain
Conference (NEUX
6000-013), Neuroscience Graduate Program, Graduate School of Biomedical Sciences,
University of Texas Medical Branch (UTMB), Galveston, Texas,
USA. (Fall Term, 20 contact hours)
I oversee the admission process, organize and
outline the curriculum, invite the participating faculty and
monitor the progress and evaluate the conference.
C. Other
2003 (May) Invited chair and speaker, Professional
Symposium on “Central sensitization in visceral pain” –
Digestive Disease Week 2003, Title of talk: “Animal models of
central sensitization in visceral pain” Orlando, Fl, USA.
2003 (Mar.) Speaker, Professional Development Course
“Stress and the Gut”, British Society of Gastroenterology,
Birmingham, UK.
2000 (Nov.) Moderator and Speaker, Professional
Development Course on the Management and Pathophysiology of
Visceral Pain, American Pain Society, 19th Annual
Meeting, Atlanta, GA, USA.
1992 Instructor of “Biomechanics of Human
Motion” at the Department of Orthopedics and Orthotics, Faculty
of Medicine, American University of Beirut (AUB), Beirut,
Lebanon.
1.
Impact of neonatal pain or injury on neural development and
adult physiology and behavior.
2.
The role of sex hormones in the gender differences seen in
visceral pain.
3.
Molecular and anatomical pathways and mechanisms of visceral
pain.
4.
The role of glial cells in the neuronal sensitization and
associated behaviors.
Translating these findings into clinical application is done
through collaboration with clinicians and pharmaceutical
companies:
5.
Effect of Allergan drugs on symptoms of irritable bowel syndrome
in rats – in collaboration with Allergan, Inc, Irvine, CA.
6.
Validation of an animal model of irritable bowel syndrome – in
collaboration with GlaxoSmithKline (GSK), Harlow, UK (completed).
Funding for these projects comes from the National Institutes of
Health in the USA or from interested pharmaceutical companies
(see funding below).
For my Research Philosophy, see Appendix (provided
on demand).
Current:
2010- Chun Lin, (MD, PhD), Postdoctoral Fellow, UAMS
2009- Martin Watts (BS), MD/PhD student, UAMS
2008- Jennifer Leigh Atchison (BS), MD/PhD student,
UAMS
2008- Krishnapraveen Yadlapalli (DVM, MS), Research
Technician, UAMS (Dr. Yadlapalli is a patch clamp
neurophysiologist)
2004- Kirsten Garner, (MS), Lab Manager (molecular
biologist)
2004- Chunping Gu, (MD, PhD), Research Associate, UAMS
(Dr. Gu is a molecular biologist)
2003- Jing Wang, (MD PhD), Visiting Scholar, UTMB, UAMS
(Dr. Wang is a neurophysiologist, she joined the faculty in
Pediatrics in 2009)
Past:
2006 (Fall)
Omar Rahal (MS), Graduate Student, UAMS
2005 - 2008 Parul Soni, (BS), Research Technician, UAMS
2002 - 2006 Xin Peng (B.S.), Research Assistant, UTMB,
UAMS
2003 - 2004 Jiangang Xie (MD, PhD), Research
Investigator, UTMB
2002 - 2004 Rodger Song (B.S.), Research Assistant, UTMB
2002 - 2003 Christine Hinze (M.S.), Research Scientist,
UTMB
2001 - 2003 Chun Lin (MD, PhD), Visiting Scientist, UTMB
2001
Kimberly Hicks (B.S.), Trainee, UTMB
2001 - 2002 Huaxian Ma (MD), Research Scientist, UTMB
2000 - 2001 Kennichi Arai (MD, PhD), Postdoctoral
Fellow, UTMB
1999 - 2000 Kawasaki, Motohiro (M.D., Ph.D.),
Postdoctoral Fellow, UTMB
1999
Broussard, Robert (MED II), Medical Student Summer Training,
UTMB
1) Active Research Grants:
B)
National Institutes of Health:
Grant 1:
“Sex Hormones and Visceral Hypersensitivity”
$1,800,000.00
Elie D. Al-Chaer, PhD:
Principal Investigator (50%)
04/01/08-03/31/13
Agency: National Institute of Digestive Diseases and Kidney
Type: RO1 DK077733
In this study, we propose to identify the hormonal basis of the
observed sexual dimorphism in visceral pain as well as the
underlying physiological mechanisms. The central hypothesis is
that sex hormones play a crucial role in the sex-specific
differences in visceral pain possibly via their action on pain
pathways in the central nervous system. Sex hormones
modulate visceral sensitivity and central neural
sensitization via direct action on estrogen receptors
located on PSDC neurons or regulation of glutamate
receptors located on these neurons. Defining
the physiological and cellular mechanisms
that contribute to sexual
differentiation in persistent visceral hypersensitivity is of
central importance to advancing our understanding of visceral
hypersensitivity and to fostering a new approach to
gastrointestinal disorders that leads to the development
of new, gender-sensitive, therapeutic tools for the management
of chronic visceral pain.
Grant 2:
“Role of Microglia in Chronic Visceral Pain”
$415,352.00
Elie Al-Chaer, Ph.D.:
Principal Investigator (20%)
06/01/09-05/31/11
Agency: National Institute of Digestive Diseases and Kidney
Type: R21DK081628
In this proposal we hypothesize that hyperactive microglia
contribute to chronic VH and neuronal hyperexcitability in the
spinal cord. First, we propose to establish a correlation
between VH and a hyperactive phenotype of microglia in rats with
CI by identifying molecular targets selective for
hyperactive microglia, and second, we propose to reverse
neuronal hyperexcitability and chronic VH by suppressing
microglial activation using minocycline or by selectively
blocking phosphorylated-p38 and P2X4 receptors, two targets
specifically expressed on hyperactive microglia. These studies
will help expand the targets of pharmacological intervention to
non-neuronal sites within the spinal cord, and improve the
analgesic potency of biologic therapies, while minimizing
undesirable side effects.
Grant 3:
“Spinal Microglial Mechanisms of Visceral Hypersensitivity”
$484,316.00
PI: Carl Y. Saab, PhD (Rhode Island Hospital)
07/01/10-06/30/12
Elie Al-Chaer, Ph.D.:
Sub-contract Principal Investigator
(20%)
Agency: National Institute of Digestive Diseases and Kidney
Type: R21
DK081845
2) Training Grants:
A)
National Institutes of Health:
Grant
1:
“Novel Mechanisms of Visceral Pain: Functional Properties of
Microglia”
PI: Jennifer L. Watts, MD-PhD
Student
7/1/09–6/30/13
Elie D. Al-Chaer, MS, PhD, JD:
co-Investigator/mentor
Role: Sponsor / Supervisor
Agency: National Institutes of Health, NIDDK
Type: 1 F30 DK084606
Grant
2:
“Alpha2-adrenoceptors modulate TRPV4 and reduce
inflammation-induced visceral pain”
PI: Martin R. Watts, MD-PhD
Student
9/1/10–8/31/14
Elie D. Al-Chaer, MS, PhD, JD:
co-Investigator/mentor
Role: Sponsor / Supervisor
Agency: National Institutes of Health, NIDDK
Type: 1 F30 DK089660
3) Institutional Grants:
A)
National Institutes of Health:
Grant
1:
“Center for Clinical and Translational Science”
$22,560,000.00
PI: Curtis L. Lowery, Jr.,
MD
09/01/09-08/31/14
Elie D. Al-Chaer, MS, PhD, JD:
co-Investigator
10%
Role: Director of Planning, co-Director of Governance
Agency: National Institutes of Health, NCRR
Type: UL1 RR029884, CTSA application
Grant 2:
“Institute for Clinical and Translational Science”
09/01/06-08/31/07
PI: Philip Kern, MD
Elie D. Al-Chaer, MS, PhD, JD:
co-Investigator (20%)
Role: Director of Planning
Agency: National Institutes of Health, NCRR
Type: P20, planning application
Grant 3:
“The Center for Translational Neuroscience”
09/01/04-07/31/09
PI: Edgar Garcia-Rill, PhD
Elie D. Al-Chaer, MS, PhD, JD:
Member (6%)
Role: Mentor
Agency: National Institutes of Health, NCRR
Type: COBRE application
4) Completed Research Grants:
B)
National Institutes of Health:
Grant 1:
“Mechanisms of Chronic Visceral Hyperalgesia”
$1,450,000.00
Elie D. Al-Chaer, PhD:
Principal Investigator
04/01/01-03/31/07
Agency: National Institute of Neurological Disorders and Stroke
Type: 1 RO1 NS/DK 40434
Grant 2:
“Visceral Pain”
Project 1 of a Program Project Grant (6 individual projects):
Program Director: William D. Willis, M.D., Ph.D.
Elie D. Al-Chaer, PhD:
Collaborator
08/01/01-07/31/04
Agency: National Institute of Neurological Disorders and Stroke
Type: 5P01 NS 11255-24
08/15/96-07/31/06
National / International:
2010 Member, NIH
Grant Application Study Section: Somatosensory and Chemosensory
Science (Pain); SCS.
2009 Panelist
on Brain-Gut Communications, Shaping the Future of Enteric
Neurosciences, Strategic Planning Forum, Chicago, IL, USA.
2009 - Member, the National Steering Committee for the
CTSA (Clinical and Translational Science Awards) Consortium, NIH,
USA.
2009 (Mar) Panelist on Chronic Pain, National Women's
Health Conference, Strategic Planning Forum, the NIH Office of
Research in Women's Health, St. Louis, MO, USA.
2008 Co-Chair, NIH Special Emphasis Panel on
Multi-disciplinary Approaches to the Study of Chronic Pelvic
Pain (MAPP) Research Network (U01 grants).
2008 Chair, American Gastroenterological
Association (AGA) Research Forum on Animal Models of Functional
and Motility Disorders. Digestive Diseases Week, San Diego, CA,
May 2008.
2007-08 Chair, AGA abstract review committee on
Animal Models of Functional and Motility Disorders for the
Digestive Disease Week (DDW), the annual meeting for digestive
diseases societies in the USA with an international membership.
2007- Member, NIH Special Emphasis Panel to review
Specialized Centers of Interdisciplinary Research (SCOR) on Sex
and Gender Factors Affecting Women’s Health (ZRG1 HOP-U).
2007- Member, NIH Grant Application Review Council:
Neural Sciences and Disorders (NSD-C).
2005- Member, Advisory Board, International Foundation
for Functional Gastrointestinal Disorders.
2005- Member, NIH Grant Application
Study Section: Somatosensory/Pain (ZRG1 IFCN-K).
2004 Chair, NIH Special Council on Mind-Body
Interactions and Health (ZRG1 RPHB-B 50 R).
2003 Member, NIH Special Emphasis Panel on Behavioral
and Social Sciences Research, a special study section to
evaluate grant applications for the “Mind-Body Interactions and
Health: Research Infrastructure Program”.
2003-05 Member, NIH Grant Application Study Section: Clinical
Neuroplasticity and Neurotransmitters (ZRG1 CNNT-01) / Brain
Disorders and Clinical Neuroscience (ZRG1 BDCN2).
2003- Invited member and co-author, Rome III
Multinational Team on Functional Gastrointestinal Disorders
Policy: a team of distinguished scientists and clinicians from
around the world that meets every 10 years to shape the clinical
and research policy of functional disorders for the next decade
(Membership by invitation only).
2001-03 Chair, American Gastroenterological
Association (AGA) abstract review committee on Colonic Motility
and Disorders for the Digestive Disease Week (DDW), the annual
meeting for all digestive diseases societies in the USA with an
international membership.
Peer-review services:
2009 - Editor-in-Chief,
International Journal of Women’s Health.
1999 - Ad-hoc reviewer for the following journals:
Neuroscience, J. Neuroscience, J. Neurophysiology, Brain
Research, Experimental Brain Research, Pain, J. Pain, European
J. Pain, Gastroenterology, Neuro-gastroenterology (since 2003),
GUT (since 2003).
Ad-hoc reviewer for the National Science Foundation (NSF), the
Veterans Administration Health System (VAHS), the National
Student Research Forum (NSRF) and a number of international
scientific and funding organizations (British, Czech, Chinese,
Japanese, etc.).
Institutional:
UAMS:
2009- Associate-Director for Governance: Center
for Clinical and Translational Research (CCTR), funded by NIH (NCRR)
through a CTSA.
2009- Executive Committee: CCTR
2004- Director, Center for Pain Research (CPR)
2007-2009 Co-Director of Governance: CCTR (Title changed in
‘09 with NIH funding)
2006-2008 Director of Planning: Planning phase, CCTR
2006-2008 Co-Director: Planning and Development, CCTR
2006-2008 Co-Director: Administrative Committee, CCTR
2006-2008 Chair, Strategic Planning Team, CCTR
2006-2008 Executive Committee, CCTR Planning
2005-2006 CUMG/Dean Grant review committee
UTMB:
2004 Chair, Examination Committee, Neuroscience
Graduate Program, Graduate School of Biomedical Sciences
2001-04 Member, Admissions Committee, School of Medicine
Review and evaluate hundreds of medical
school applications and interview and rank hundreds of
applicants every year.
2001-04 Member, Examination Committee, Neuroscience Graduate
Program, Graduate School of Biomedical Sciences
Oversee the Neuroscience Graduate Program
Qualifying Exam, by evaluating the questions, the corrections
and the grading.
2001 Coordinator, Seminars and Annual Meeting, Gulf
Coast GI Research Forum
2000-03 Member, Grant Review Committee, the Gastrointestinal
Research Interdisciplinary Program (GRIP)
2000-03 Member, Seminar Committee, GRIP
Departmental:
2005 - Member, Mentoring Committee, Department of
Pediatrics, College of Medicine, University of Arkansas for
Medical Sciences (UAMS), Little Rock, AR, USA.
2005 - Member, Graduate Advisory Committee, Neurobiology
and Developmental Sciences, College of Medicine, UAMS.
2000 - 2003 Chair, Postgraduate Pain Program
Sub-Committee, Department of Anatomy and Neurosciences,
University of Texas Medical Branch (UTMB), Galveston, TX, USA.
Objectives: Provide an interactive
educational forum for scientists and clinicians interested in
Pain management and Research.
1999 - 2004 Member, Program Project Grant Committee,
Pain Group, Department of Anatomy and Neurosciences, UTMB
1998 - 2002 Webmaster of GI Web, The website development
team for the Division of Gastroenterology, UTMB.
http://www2.utmb.edu/gastroenterology
Other:
Graduate Students Exam Committees
I mentored, co-mentored and served on the graduate exam
committee of the following students:
2009 - Graduate School External Examiner
Hong Kong Baptist University
Doctor of Philosophy Degree Programme
Student: Zhang Jianliang
Supervisor: Dr. Zhang Hongqi
Thesis Title:
Electroacupuncture vs Vagus Nerve Stimulation for Epilepsy
2009 - Mentor and PhD Thesis Supervisor, UAMS
Martin Watts, MD/PhD student
2008 - Mentor and PhD Thesis Supervisor, UAMS
Jennifer Leigh Atchison, MD/PhD student
2008 - Neuroscience Graduate Program Examiner, UAMS.
Student: Dong, Chaoxuan (Ph.D.
Candidate).
Supervisor: Anand, Kanwaljeet S. MBBS,
D Phil.
Thesis Title:
“Effects of Ketamine on Apoptosis and Neurogenesis of Rat Fetal
Cortical Neural Stem / Progenitor Cells (NSPCs)”
2007 - 09 Neuroscience Graduate Program Examiner, UAMS.
Student: Ye, Meijun (Ph.D.
Candidate).
Supervisor: Garcia-Rill, Edgar Ph.D.
Thesis Title:
“Cholinergic Modulation of Fast Synaptic Transmission in the
Pedunculopontine and Parafascicular Nuclei: Implications for the
Regulation of Cortical Arousal”
2008 Graduate School External Examiner
Hong Kong Baptist University
Doctor of Philosophy Degree Programme
Student: Zhang Xiaojun
Supervisor: Dr. Bian ZhaoXiang
Thesis Title:
Analgesic Effect of Paeoniflorin in Rats with Visceral
Hyperalgesia Induced by Neonatal Maternal Separation
2005 - 2006 Neuroscience Graduate Program Examiner,
UAMS.
Student: Fann, Alice MD (Ph.D.
Candidate).
Supervisor:
Garcia-Rill, Edgar Ph.D.
Thesis Title:
“Chronic Low Back Pain: Arousal, Attention, and Frontal Lobe
Blood Flow Dysfunctions”
2000 - 2003 Neuroscience Graduate Program Faculty
Examiner, UTMB.
Student:
Vera-Portocarrero, Louis P. (Ph.D. Candidate).
Supervisor:
Westlund-High, Karin N. Ph.D.
Thesis Title: “Descending modulation
and visceral pain”
1999 - 2001 Neuroscience Graduate Program Faculty
Examiner, UTMB.
Student: Hains, Bryan (Ph.D.
Candidate).
Supervisor: Hulsebosch, Claire E.,
Ph.D.
Thesis Title: “Transplant therapy and
cellular mechanisms contributing to chronic pain after spinal
cord injury.”
1999 - 2001 Neuroscience Graduate Program Faculty
Examiner, UTMB.
Student: Saab, Carl (Ph.D.
Candidate).
Supervisor: Willis, William D. M.D.,
Ph.D.
Thesis Title: “Role of the cerebellum
in Pain.”
Co-Mentored Publications:
1) Saab C.Y., Kawasaki M., Al-Chaer E.D. and
Willis, W.D. Cerebellar cortical stimulation increases spinal
visceral nociceptive responses. J. Neurophysiol. 85(6):
2359-2363, 2001
2) Saab, C.Y.,
Kawasaki M., Masaad, C.A., Saadé, N.E., Al-Chaer, E.D.
and Willis W.D. Is the cerebellum involved in analgesia or Pain?
Society for Neuroscience, 2000
3) Saab C.Y., Kawasaki M, Al-Chaer E.D. and Willis
W.D. Cerebellar modulation of spinal nociceptive responses: Can
pain be influenced from the cerebellum? American Pain society,
19th Annual Scientific Meeting, Atlanta, Georgia, November 2-5,
2000
2006 - DC Bar Association, member
2003 - 04 Galveston County Bar Association, member
2003 - 04 Galveston County Young Lawyers Association, member
2003 - Rome Foundation for Gastrointestinal Disorders,
member
2002 - Texas Young Lawyers Association, member
2002 - American Bar Association (ABA), member
2002 - State Bar of Texas, member
2002 - 04 Chair, American Gastroenterological Association
(AGA) committee on Colonic Motility and Disorders.
1998 - American Gastroenterological Association (AGA),
member
1997 - 02 American Bar Association (ABA), student member
1996 - American Pain Society (APS), member
1996 - American Association for the Advancement of
Science (AAAS), member
1995 - American Physiological Society, member
1995 - International Association for the Study of Pain (IASP),
member
1993 - Society for Neuroscience, member
2006 (Feb. 3) – Washington DC Bar, Licensed attorney by the
District of Columbia Court of Appeals to practice in all the
courts of the District of Columbia.
2002 (Nov. 6) – State Bar of Texas, Licensed attorney and
counselor at law by the Supreme Court of Texas to practice in
all courts of the State of Texas.
Additional Information
A. Honors, Scholarships and Awards
Science related honors:
2009 Plenary speaker, The Institute of Chinese Medicine Forum
on Irritable bowel syndrome: “When East Meets West”, Title of
talk: “Irritable Bowel Syndrome: A Tale of Sex, Drugs and
Pain” The Golden Egg Auditorium, Hong Kong Science Park,
Shatin, Hong Kong, China.
2006 Plenary speaker at the joint conference of the American
Gastroenterological Association (AGA) and the British Society of
Gastroenterology (BSG), Title of talk: “Neuroplasticity in
visceral pain”, Cambridge, UK.
2003 Plenary speaker, professional development course, the
British Society of Gastroenterology
2003 Plenary speaker, Spring Brain Conference, Title of talk:
“The role of the dorsal columns in pain states” Sedona,
AZ, USA.
2002 Invited speaker on “The art and science of visceral
pain: from neonatal plasticity to adult perception” the Pain
Research Center, the Brigham and Women’s Hospital, Harvard
Medical School, Boston, MA, USA.
2002 Invited to evaluate a $7.5 Million Program Project Grant
and to speak on“Plasticity of visceral pain circuitry in
adult rats with neonatal colon injury”, Pain Program,
University of Maryland Dental School, Baltimore, MD, USA.
2000 The John C. Liebeskind Early Career Scholar Award,
for
exceptional accomplishment and promise in pain scholarship,
American Pain Society
1999 Outstanding Educator Award, Generalist Physician
Investigator Program, UTMB
1998 American Pain Society, Young Investigator Travel Award
1997 The James E. Beall II Memorial Award in Anatomy and the
Neurosciences
1996 The Mustard Seed Award in Research for outstanding
research and service in cancer pain, offered by the Sealy
Society
1995 Who’s Who Among Students in American Universities
and Colleges
1990 Diana Tamari Sabbagh (DTS) Award for outstanding
researchers in medical sciences
Law related awards:
2001 Phi Beta Phi, International Legal Fraternity,
Highest Grade award In International Law.
2001 Who’s Who among American Law Students
1999 - 2002 Dean’s Honor List, South Texas College of
Law
1999 Invited to write for Law Review, South Texas
College of Law
1997 Outstanding Academic Achievement (1st
Term), South Texas College of Law
Other awards:
1985 AUB scholarship for an outstanding undergraduate
student
2005- Member, Advisory Board, International Foundation
for Functional Gastrointestinal Disorders (IFFGD), USA.
2004- Member, Visceral Pain Advisory Board, Allergan Inc,
Irvine, CA, USA
2003-04 Strategic consultant, Governing Board, Sigma Health
Care, Inc. Galveston, TX, USA.
2003- Member, Pain Advisory Board, Allergan Inc, Irvine,
CA, USA
2000-04 Member,
Professional Advisory Committee, Sigma Health Care, Inc.
Galveston, TX, USA.
1999- Biomedical research professional consultant,
Allergan Inc, Irvine CA, USA
2010 (Jan) Invited speaker, Perinatal Research Rounds, The
University of Chicago – Pritzker School of Medicine and the
NorthShore University Health System, Title of rounds: “Visceral
Pain: Insights from the Platonic Fold” Evanston, IL, USA.
2010 (Jan) Invited speaker, Medicine and Obstetrics Gynecology
Grand Rounds, The University of Chicago – Pritzker School of
Medicine and the NorthShore University Health System, Title of
grand rounds: “Pain the Paradox of Scientific Advances and
Clinical Retreats” Chicago, IL, USA.
2010 (Jan) Invited speaker, Nationwide Children’s Hospital and
Ohio State University, Title of talk: “Age, Pain and
Neuroplasticity: Scientific Constructs and Outcome Realities”
Columbus, OH, USA.
2009 (Oct) Keynote speaker, Arkansas Chapter of the Society for
Neuroscience, Title of talk: “Neuroplasticity in Animal
Models of Pain” Little Rock, AR, USA.
2009 (July) Invited seminar, Eli Lilly and Company Pain and
Migraine Drug Hunting Team, Title of seminar: “Visceral Pain:
Insights from the Platonic Fold” Indianapolis, IN, USA.
2009 (Apr) Invited workshop, the 8th International
Symposium on Functional Gastrointestinal Disorders, Title of
workshop: “Pain Pathways” Milwaukee, WI, USA.
2009 (Mar) Invited plenary speaker, The Institute of Chinese
Medicine Forum on Irritable Bowel Syndrome: “When East Meets
West”, Title of Talk: “Irritable Bowel Syndrome: A Tale of
Sex, Drugs and Pain” Hong Kong Science Park, Shatin, Hong
Kong.
2008 (Oct) Invited speaker, Department of Medicine, State
University of New York (SUNY) Downstate Medical Center, Title of
Talk: “Functional Abdominal Pain: a Gut Feeling in the
Brain”, Brooklyn, NY, USA.
2008 (Apr) Invited speaker, Rural Hospital Program, Title of
Talk: “Pain: a Primer on Neural Mechanisms and Management”
(satellite broadcast) Little Rock, AR, USA.
2007 (Apr) Invited plenary speaker, the 6th
International Symposium on Functional Gastrointestinal
Disorders, Title of Talk: “Neuroplasticity and Functional
Pain” Milwaukee, WI, USA.
2007 (Apr) Invited workshop, the 6th International
Symposium on Functional Gastrointestinal Disorders, Title of
workshop: “Pain Pathways” Milwaukee, WI, USA.
2006 (Oct) Distinguished lecture, the Oklahoma Center for
Neuroscience and the Department of Physiology, Oklahoma
University Health Science Center. Title of talk: “Visceral Pain:
Reflections on Phylogeny, Physiology and Pathways”, Oklahoma
City, OK, USA.
2006 (Sep) Invited Speaker, Queen Mary, University of London
and The Royal London Hospital, Title of Talk: “Visceral Pain:
The Rhapsody of a Nervous System”, invited speaker, London,
England, UK.
2006 (Sep) Plenary lecture, the joint conference of the American
Gastroenterological Association (AGA) and the British Society
for Gastroenterology. Title of talk: “Neuroplasticity in
Visceral Pain”, Cambridge University, England, UK.
2006 (Jul) Plenary lecture, the Brain-Gut Symposium held at St.
Anne’s College, Oxford University. Title of talk: “Animals
Models of Visceral Pain”, Oxford, England, UK.
2005 (June) Invited Speaker, The University of Florida
Comprehensive Center for Pain Research and the College of
Dentistry Dean’s Seminar Series, Title of talk: “Functional
Pain: the Rhapsody of a Nervous System” The University of
Florida, Gainesville, FL, USA.
2005 (Apr) Invited plenary speaker, the 6th
International Symposium on Functional Gastrointestinal
Disorders, Title of Talk: “Neuroplasticity and Functional
Pain” Milwaukee, WI, USA.
2005 (Apr) Invited workshop, the 6th International
Symposium on Functional Gastrointestinal Disorders, Title of
workshop: “Pain Pathways” Milwaukee, WI, USA.
2005 (Mar) Invited Physiology Seminar, Title of talk: “Behavioral
and Neural Changes in Adult Rats Exposed to Neonatal Colon
Injury” Department of Physiology, College of Medicine, UAMS.
2005 (Feb) Invited Neurology Grand Rounds, Title of talk: “Pain:
Reflections on Phylogeny, Physiology and Pathways”
Department of Neurology, College of Medicine, UAMS
2005 (Feb) Seminar, “Pain: the Rhapsody of a Nervous System”
Pain Arkansas Club, UAMS.
2005 (Jan) Invited Neurosurgery Grand Rounds, Title of talk: “Visceral
Pain: Mechanisms, Pathways and Surgical Solutions”
Department of Surgery, College of Medicine, UAMS.
2003 (Nov) Guest Speaker, The Arkansas Children’s Hospital and
the Department of Pediatrics at the University of Arkansas
Medical School, Title of talk: “Neonatal injury: an etiology
of functional pain in adults” Little Rock, AR, USA.
2003 (May) Invited Chair and Speaker, Symposium on Central
Sensitization, Title of talk: “Animal models of
sensitization” Digestive Diseases Week 2003, Orlando, FL,
USA.
2003 (Mar.) Invited Plenary Speaker, Postgraduate Professional
Development Course - British Society of Gastroenterology, Title
of talk: “Neonatal stressors and adult visceral
hypersensitivity in GI disease” Birmingham, UK.
2003 (Mar.) Invited Plenary Speaker, Spring Brain Conference,
Plenary Session III, Title of talk: “The role of the dorsal
columns in pain states” Sedona, AZ, USA.
2003 (Feb.) Guest Speaker, The Pain Advisory Board for Allergan
Inc, Title of Talk: “Pharmacological validation of an animal
model of chronic functional abdominal pain” Irvine, CA, USA.
2002 (Sep.) Moderator, Symposium on Basic Science – American
Motility Society. Galveston, TX, USA.
2002 (June) Guest Speaker, The Pain Research Center at the
Brigham and Women’s Hospital, Harvard University. Title of talk:
“The art and science of visceral pain: from neonatal
plasticity to adult perception” Boston, MA, USA.
2002 (April) Speaker, The Spring Pain Research Conference. Title
of talk: “Chronic abdominal pain: the ghost of a painful past”
Grand Cayman, British West Indies.
2002 (April) Speaker, GlaxoSmithKline/Cambridge University
Symposium. Title of talk: “Functional bowel disorders in an
animal model of chronic visceral pain” Harlow, UK.
2002 (Mar.) Speaker, NIH Symposium: Oral, Craniofacial and
Persistent Deep Pain. Title of talk: “Neural plastic changes
initiated by neonatal injury: the culprit in chronic visceral
pain” Baltimore, MD, USA.
2002 (Mar.) Guest Speaker, University of Maryland Dental School,
Pain Program. Title of talk: “Plasticity of visceral pain
circuitry in adult rats with neonatal colon injury”
Baltimore, MD, USA.
2001 (Nov.) Speaker, The 2nd Annual International
Course and Workshop On Gastrointestinal Motility/Functional
Disorders. Title of talk: “Biological Basis of Abdominal
Pain” Galveston, TX, USA.
2001 (Sep.) Speaker, The 18th International Symposium
on Neurogastroenterology and Motility. Title of talk:
“Painful neonatal memories and functional bowel disorders”
Madison, Wisconsin, USA.
2001 (July) Speaker, “2001: A Brain-Gut Odyssey” meeting of the
International Society for Brain-Gut Studies. Title of talk:
“On the Journey of Pain: from Gut to Brain” University of
Oxford, Oxford, UK.
2001 (May) Speaker, “Evolving Animal Models for Functional
Gastrointestinal Disorders” a research symposium at the
Digestive Diseases Week, 2001. Title of talk: “Rat Model of
Persistent Visceral Hyperalgesia Following Early Life Gut
Irritation” Atlanta, GA, USA.
2001 (April) Speaker, Seminar series at CURE, University of
California at Los Angeles. Title of talk: “Chronic Abdominal
Pain: The Wounds That Never Heal” Los Angeles, CA, USA.
2000 (Dec.) Speaker, International Course on Motility and
Functional Bowel Disorders. Title of talk: “The Pathogenesis
of Visceral Hyperlagesia.” Galveston, TX, USA.
2000 (Dec.) Coordinator and Speaker, Symposium on
Gastrointestinal Pain. Title of talk: “An Animal Model of
IBS: The Key to the Puzzle in a Long Abandoned Challenge?”
University of Texas Medical Branch, Galveston, TX, USA.
2000 (Nov.) Chair and Speaker, Professional Development Course
for the American Pain Society, Atlanta, GA, USA. Title of talk:
“Management of chronic visceral pain: an overview of basic
research, psychophysics, symptoms, treatments and social
correlates.”
1999 (Oct.) Chair and Speaker, Symposium for the American Pain
Society, Ft. Lauderdale, FL: “Pathogenesis, pathways and
processing of colon pain: a “state of the science” address.”
1999 (Oct.) Speaker, Lecture for the Society for Neuroscience, “Pain
Research - On the Threshold of a New Millennium.” Miami, FL.
1999 (May) Speaker, Seminar given for the Neuroscience Graduate
Program, University of Texas Medical Branch, Title of talk: “Ode
to an Empty Bowel” Galveston, Texas.
1998 (May) Speaker, Seminar, Digestive Disease Week 98, Title of
talk: “A quantitative basis for the dorsal column dominant
role in visceral pain”. New Orleans, LA, USA.
1996 (Oct.) Speaker, Dissertation Defense Seminar, Dept. of
Anatomy and Neurosciences, University of Texas Medical Branch,
Title of talk: “The role of the dorsal column in visceral
pain”; Galveston, Texas, USA.
1996 (Feb.) Speaker, Seminar given at the University of
Oklahoma, Health Sciences Center. Title of talk: “The role of
the dorsal column in visceral pain” Oklahoma City, OK.
1995 (Jan.) Speaker, Dissertation Proposal seminar for the
degree of Doctor of Philosophy, Dept. of Anatomy and
Neurosciences, UTMB, “Visceral input into the ventral
posterolateral nucleus of the thalamus: a pathway in the
fasciculus gracilis involving the postsynaptic dorsal column
system” Galveston, Texas, USA.
1994 (Aug.) Speaker, Seminar given at the Dept. of Anatomy and
Neurosciences, UTMB, title of talk: “Viscero-somatic
interactions in the thalamus: a possible role of the dorsal
column” Galveston, Texas, USA.
1991 (July) Speaker, Dissertation Defense seminar for the degree
of Master of Sciences, Dept. of Physiology, Faculty of Medicine,
AUB. Title of talk: “Dorsal column input into the nucleus
locus coeruleus” Beirut, Lebanon.
1990 (June) Speaker, Seminar given at the dept. of
Physiology, AUB. Title of talk: “The role of the nucleus
locus ceoruleus in antinociception” Beirut, Lebanon.
D. Making News
2006: Interviewed on the live broadcast of Voice of
America’s (VOA) daily international radio discussion “Talk to
America”, Nov. 14, 2006, on the topic of Pain. "Talk to America"
is the world's only international daily call-in/discussion
program, broadcast in English Monday through Friday and aired
over VOA's global short-wave transmitter network, as well via
satellite, local radio stations overseas and the Internet.
http://www.voanews.com/talk.
2005: Featured in “the Buzz”, a UAMS Newsletter.
1999: Interviewed by Science News for an article
entitled “Pain, Pain, Go Away” Science News 155: 108-110,
February 1999.
1999: Interviewed by BioPhotonics International
for an article entitled “Functional MRI shows pathway for
visceral pain” BioPhotonics International pp. 26-28,
March/April 1999.
1999: Featured in the UTMB Quarterly, pp. 18-21,
Fall 1999.
1999: Interviewed by the British Broadcasting
Corporation (BBC), Science Department, for a program entitled
BBC Horizon on October 07, 1999.
1999: Interviewed by Medscape, CBS on October 23rd,
1999.
1998: Interviewed by IMPACT (UTMB Newsletter)
for an article entitled “Researchers determine how gut pain
affects the brain. IMPACT 22 (20): 3, November 16, 1998.
1998: Interviewed by Radiology and Imaging Letter
for a Feature Article entitled “Researchers use Brain fMRI to
find New Pathway to Resolve Pelvic Pain.” RIL 18 (21):
163 – 165, December 1, 1998.
1996: Featured in the Galveston County Daily News
under “UTMB Society awards 5 for services” The Galveston
County Daily News 154 (61): 7-A, Monday June 10, 1996.
1996: Featured in IMPACT (UTMB Newsletter) as
the recipient of the Sealy Society Mustard Seed Award in
Research for 1995. IMPACT 20 (12): 1-2, June 17, 1996.
1988: Interviewed by “Le Nouveau Magazine”
(weekly political, economical and cultural Middle Eastern
magazine in French) for an article entitled “Le Club Culturel de
L’OCP en mission diplomatique.” Le Nouveau Magazine No.
1591, January 30 1988.
Publications
A. Articles in Peer-Reviewed Journals
1. Al-Chaer, E.D., Lawand, N.B., Westlund, K.N.
and Willis, W.D. Visceral nociceptive input into the ventral
posterolateral nucleus of the thalamus: a new function of the
dorsal column. J. Neurophysiol. 76:2661-2674, 1996.
2. Al-Chaer, E.D., Lawand, N.B., Westlund, K.N.
and Willis, W.D. Pelvic visceral input into the nucleus
gracilis is largely mediated by the postsynaptic dorsal column
pathway. J. Neurophysiol. 76: 2675-2690, 1996.
3. Hirshberg, R.M., Al-Chaer, E.D., Lawand,
N.B. Westlund, K.N. and Willis, W.D. Is there a pathway in the
dorsal funiculus that signals visceral pain? Pain 67:291-305,
1996.
4. Al-Chaer, E.D., Westlund, K.N. and Willis, W.D.
Potentiation of thalamic responses to colorectal distension by
visceral inflammation. NeuroReport 7:1635-1639, 1996.
5. Al-Chaer, E.D., Westlund, K.N. and Willis, W.D.
The dorsal column: A possible role in visceral hyperalgesia.
In Jensen, T.S., Turner, J.A. and Wiesenfield-Hallin, Z. (ed):
Proceedings of the 8th world congress on pain, vol. 8,
1997, pp. 839-853.
6. Al-Chaer, E.D., Westlund, K.N. and Willis, W.D.
The nucleus gracilis: an integrator for visceral and somatic
information. J. Neurophysiol.
78:521‑527, 1997.
7. Al-Chaer, E.D., Westlund, K.N. and Willis, W.D.
Effects of colon inflammation on the responses of postsynaptic
dorsal column cells to visceral and cutaneous stimulation.
NeuroReport
8: 3267-3273, 1997.
8. Al-Chaer, E.D., Feng, Y. and Willis, W.D. A
role for the dorsal column in nociceptive visceral input into
the thalamus of primates. J. Neurophysiol.
79 (6): 3143-3150, 1998.
9. Feng, Y., Cui, M., Al-Chaer, E.D. and Willis,
W.D. Epigastric antinociception by cervical dorsal column lesion
in rats. Anesthesiology 89 (2): 411-420, 1998.
10. Al-Chaer, E.D., Feng, Y. and Willis, W.D. A
comparative study of viscerosomatic input onto postsynaptic
dorsal column and spinothalamic tract neurons in the primate.
J. Neurophysiol.
82 (4):1876-1882, 1999.
11. Willis, W.D., Al-Chaer, E.D., Quast, M. J. and
Westlund, K. N. A visceral pain pathway in the dorsal column of
the spinal cord. In: The Neurobiology of Pain. By: The National
Academy of Sciences
(USA). PNAS
96 (14): 7675-7679, 1999.
12. Saab C.Y., Makki A., Quast M., Wei J., Al-Chaer E.D.,
Willis W.D. Is the cerebellum involved in pain? In:
Proceedings of the 9th World Congress on Pain, vol 16. IASP
Press, Seattle, pp 515–522, 2000.
13.
Al-Chaer, E.D.,
Kawasaki, M. and Pasricha, P.J. A new model of chronic visceral
hypersensitivity: in adult rats induced by colon irritation
during postnatal development. Gastroenterology 119:
1276–1285, 2000.
14. Saab C.Y., Kawasaki M., Al-Chaer E.D. and
Willis, W.D. Cerebellar cortical stimulation increases spinal
visceral nociceptive responses. J. Neurophysiol. 85(6):
2359-2363, 2001.
15.
Zhang, H.Q., Al-Chaer,
E.D. and
Willis, W.D. Effect of tactile inputs on thalamic
responses to noxious colorectal distension in rat.
J. Neurophysiol.
88:1185-1196, 2002.
16. Zhang, H.Q., Rong, P.J., Zhang, S.P., Al Chaer, E.D.
and Willis, W.D. Noxious visceral inputs enhance cutaneous
tactile responses in rat thalamus. Neurosci. Lett. 336:109-112,
2003.
17. Lin, C. and Al-Chaer, E.D. Long-term
sensitization of primary afferents in adult rats exposed to
neonatal colon pain. Brain Res. 971: 73-82, 2003.
18. Kawasaki, M. and Al-Chaer, E.D. Intradermal
capsaicin inhibits lumbar dorsal horn neuronal responses to
colorectal distension. NeuroReport 14 (7): 985-9, 2003.
19. Arai, Y-C.P., Ueda, W. and Al-Chaer, E.D.
Pre-anesthetic maternal separation increases pups' locomotor
behavior during emergence from anesthesia in rats. Acta
Anaesthesiol Scand 48: 174-177, 2004.
20. Saab, C.Y., Arai, Y-C.P. and Al-Chaer, E.D.
Modulation of visceral nociceptive processing in the lumbar
spinal cord following thalamic stimulation or inactivation and
after dorsal column lesion in rats with neonatal colon
irritation. Brain Res. 1008 (2): 186-192, 2004.
21. Arai, Y-C.P., Ueda, W and Al-Chaer, E.D.
Pre-anesthetic presence of an injured dam influences pups’
locomotor behavior during emergence from anesthesia in rats.
Acta Anaesthesiol Scand 49: 166-169, 2005.
22. Lin, C and Al-Chaer, E.D. Differential effects
of glutamate receptor antagonists on dorsal horn neurons
responding to colorectal distension in a neonatal colon
irritation rat model. World J Gastroenterol 41:6495-6502, 2005.
23. Grundy, D.,
Al-Chaer, E.D., Aziz, Q., Collins, S.M., Ke, M., Tache,
Y., Wood, J.D.
Fundamentals of neurogastroenterology: basic science.
Gastroenterology
130(5):1391-1411, 2006.
24. Saab, C.Y., Wang J., Gu, C., Garner, K.N. and
Al-Chaer, E.D. Microglia: A newly discovered role in
visceral hypersensitivity? Neuron Glia Biology 2:
271-277, 2006.
25. Hayar A.M., Gu C. and Al-Chaer E.D. An
improved method for patch clamp recording and calcium imaging of
neurons in the intact dorsal root ganglion in rats. J.
Neurosci. Methods 173(1): 74-82, 2008.
26. Wang, J., Gu, C. and Al-Chaer, E.D. Altered
behavior and digestive outcomes in adult male rats primed with
minimal colon pain as neonates. Behav Brain Funct. 4(1):
28, 2008.
27. Chaloner A., Rao A., Al-Chaer E.D.,
Greenwood-Van Meerveld B. Importance of neural mechanisms in
colonic mucosal and muscular dysfunction in adult rats following
neonatal colonic irritation. Int J Dev Neurosci. 28(1):99-103,
2010.
28. Romanovsky D., Wang J., Al-Chaer E.D., Stimers
J.R., Dobretsov M. Comparison of metabolic and neuropathy
profiles of rats with streptozotocin-induced overt and moderate
insulinopenia. Neuroscience. 170(1):337-347, 2010.
B. Reviews
1. Al-Chaer, E.D., Feng, Y. and Willis, W.D.
Visceral pain: a disturbance in the sensorimotor continuum?
Pain Forum 7 (3): 117-125, 1998.
2. Al-Chaer, E.D. and Traub R.J. Biological basis
of visceral pain: recent developments. Pain 96: 221-225,
2002.
3. Grundy D, Al-Chaer ED, Aziz Q, Collins SM, Ke
M, Tache Y, Wood JD.
Fundamentals of
neurogastroenterology: basic science.
Gastroenterology
130(5):1391-1411, 2006.
C. Articles Submitted / In Press
Wang, J., Gu, C., Garner K.N. and Al-Chaer, E.D.
Sex differences in the processing of viscerosensory information.
D. Other (Book Chapters)
1. Willis, W.D., Al-Chaer, E.D., Quast, M. J. and
Westlund, K. N. Evidence for the presence of a visceral pain
pathway in the dorsal column of the spinal cord. In
Somatosensory processing: from single neuron to brain imaging.
Editors: Rowe, M.J. and Iwamura Y. pp. 51-75, 2001. Harwood
Academic Publishers, Amsterdam, The Netherlands.
2. K. J. S. Anand, A. T. Bhutta, R. W. Hall, C. R. Rovnaghi, and
E. D. Al-Chaer. Long-term effects of repetitive
pain in the neonatal period: neuronal vulnerability, imprinting,
and plasticity. In Neonatal Pain, Hodgson DM (Ed), Section IV,
Chapter 15, pp. 197 – 210, Taylor and Francis Medical Books,
London, 2005.
3. Al-Chaer, E.D. Descending Modulation of
Visceral Pain. In Descending Modulation of Spinal Nociceptive
Processing. Section Editor: Ronald Dubner. Encyclopedia of
Pain. Schmidt R. and Willis W.D. Springer-Verlag, Heidelberg,
Germany, 2006, pp. 576-578.
4. Al-Chaer, E.D. Visceral Pain / Irritable Bowel
Syndrome Model. In Animal Models and Experimental Tests to
Study Nociception and Pain. Section Editor: Jin Mo Chung.
Encyclopedia of Pain. Schmidt R. and Willis W.D. Springer-Verlag,
Heidelberg, Germany, 2006, pp. 2623-2626.
5. Wood JD, Grundy D, Al-Chaer ED, Aziz Q, Collins
SM, Ke M, Tache Y.
Fundamentals of
neurogastroenterology: basic science. In ROME III, The
Functional Gastrointestinal Disorders, 3rd Ed.
(Drossman et al. Eds.), Degnon Associates, Inc. McLean, VA, pp.
31-88, 2006.
6. Al-Chaer, E.D. Postsynaptic Dorsal Column
Neurons, Responses to Visceral Input. In Ascending
Transmission of Nociceptive Signals. Section Editor: Glenn
J. Giesler Jr. Encyclopedia of Pain. Schmidt R. and Willis W.D.
editors. Springer-Verlag, Heidelberg, Germany, 2006, pp.
1954-1956.
7. Al-Chaer, E.D. and Willis W.D. Neuroanatomy of
visceral pain: Pathways and processes in “Chronic abdominal and
visceral pain: theory and practice” PJ Pasricha, WD Willis and
GF Gebhart (Eds), Chapter 4, pp. 33-44, Informa Health Care,
Inc. New York, NY, 2007.
8. Anand KJS, Al-Chaer ED, Bhutta AT and Hall RW.
Development of Supraspinal Pain Processing. In: 3rd Edition of
“Pain in Neonates & Infants” (Anand, Stevens, McGrath Eds.) Pain
Research and Clinical Management, Chapter 3, Elsevier
Churchill-Livingstone, Edinburgh, pp. 25-44, 2007.
9. Sternberg W.F. and Al-Chaer, E.D. Long-term
Consequences of Neonatal and Infant Pain from Animal Models. In:
3rd Edition of “Pain in Neonates & Infants” (Anand, Stevens,
McGrath Eds.) Pain Research and Clinical Management, Chapter 5,
pp. 57-66, Elsevier Churchill-Livingstone, Edinburgh, 2007.
10. Al-Chaer, E.D. and Hyman, P.E. Visceral pain
in infancy, In: 3rd Edition of “Pain in Neonates & Infants”
(Anand, Stevens, McGrath Eds.) Pain Research and Clinical
Management, Chapter 14, pp. 201-210, Elsevier
Churchill-Livingstone, Edinburgh, 2007.
11. Al-Chaer, E.D. Visceral Pain. In “Mechanisms
of Pain in Peripheral Neuropathy” (Maxim Dobrestov and Jun
Ming Zhang, Eds), chapter 2, pp 29 – 45, 2008.
12. Al-Chaer, E.D. The Neuroanatomy of Pain and
Pain Pathways, In “Biobehavioral Approaches to Pain” (Rhonda J.
Moore, Editor), Chapter 2, pp 17 - 44, Springer, New York, 2009.
13. Elie D. Al-Chaer and Shelley A. Weaver. Early
life trauma and chronic pain. In “Functional Pain Syndromes:
Presentation and Pathophysiology”, (Emeran A. Mayer and M.
Catherine Bushnell, Editors),
Chapter 20, pp 423 – 454, IASP press, Seattle, WA, 2009.
E. Abstracts
1. Jabbur, S.J., El-Chaer, E., Atweh, S.F. and
Saadé, N.E. Activation of locus coeruleus neurons by dorsal
column (DC) stimulation (st). Society for Neuroscience
Abstracts, 1991, 17:292.
2. Al-Chaer, E.D., Saadé,N.E., Atweh, S.F.
and Jabbur, S.J. Dorsal column input into the nucleus locus
ceoruleus in cat. Lebanese Association for the Advancement of
Science Abstracts, 1992, 11:194.
3. Jabbur, S.J., Atweh, S.F., Al-Chaer, E.D.
and Saadé, N.E. Modulation of discharges of cuneate neurons (CN)
by conditionning stimuli to the lateral and medial vestibular
nuclei. Society for Neuroscience Abstracts, 1993, 19:329.
4. Rees, H., Tsuruoka, M., Al-Chaer, E.D.
and Willis, W.D. Excitation and inhibition of STT cells by
stimulation of the pretectal region in the anesthetized
primate. J. Physiol. Proc. 4760: 47, 1994.
5. Al-Chaer, E.D., Rees, H., Tsuruoka, M. and
Willis, W.D. Facilitation of superficial STT cells by
stimulation of the pretectal region in the primate. Society for
Neuroscience Abstracts, 1994, 20:548.
6. Hirshberg, R.M., Al-Chaer, E.D., Lawand, N.B.,
Westlund, K.N. and Willis, W.D. Is there a pathway in the
dorsal funiculus that signals visceral pain? 10th European
Congress of Neurosurgery Abstracts, Berlin 1995.
7. Al-Chaer, E.D., Lawand, N.B., Westlund, K.N.
and Willis, W.D. The dorsal column is more important for
visceral pain than the spinothalamic tract? Society for
Neuroscience Abstracts, 1995, 21:644.
8. Lawand, N.B., Al-Chaer, E.D., Westlund, K.N.
and Willis W.D. Administration of morphine and CNQX in the rat
sacral cord blocks the responses of dorsal column nuclei (DCN)
cells to visceral but not to cutaneous stimulation. Society for
Neuroscience Abstracts, 1995, 21:644.
9. Al-Chaer, E.D., Westlund, K.N. and Willis, W.D.
The dorsal column: a possible role in visceral hyperalgesia.
International Association for the Study of Pain Abstracts, 1996
10. Westlund, K.N., Hirshberg, R.M., Lawand, N.B.,
Al-Chaer, E.D. and Willis, W.D. Anatomical evidence for
a visceral pain pathway in the dorsal column. International
Association for the Study of Pain Abstracts, 1996.
11. Al-Chaer, E.D., Westlund, K.N. and Willis, W.D.
Modulation of viscero-somatic interactions in the thalamus by
dorsal column input. Society for Neuroscience Abstracts, 1996.
12. Westlund, Al-Chaer, E.D. and Willis, W.D. The
nucleus gracilis (NG): a cross road for pelvic visceral and
cutaneous inputs into the thalamus. Society for Neuroscience
Abstracts, 1996.
13. Al-Chaer, E.D., Westlund, K.N. and Willis, W.D.
Effects of colon inflammation on neuronal responses to
colorectal distension and cutaneous stimuli. Gulf Coast GI
Research Forum, 1996.
14. Rees, H., Houghton, K.A. Chen, P.-S., Al-Chaer, E.D.,
Westlund, K.N. and Willis, W.D. Anterior pretectal inhibition
is blocked by spinal administration of strychnine but not
blocked by
"2-adrenoceptor
antagonists in the anaesthetized primate . J. Physl.
Lon. 4950: 20, 1996.
15. Al-Chaer, E.D., Feng, Y., Westlund, K.N. and
Willis, W.D. The dorsal column: a role in nociceptive
viscerosensory processing in the primate. Society for
Neuroscience Abstracts, 1997.
16. Lawand, N.B., Al-Chaer, E.D., Willis W.D. and
Westlund, K.N. Metabotropic glutamate receptors in the knee
joint: a possible role in peripheral sensitization. Society for
Neuroscience Abstracts, 1997.
17. Willis, W.D., Westlund, K.N. and Al-Chaer, E.D.
Spinal pathways for colorectal input into the solitary nucleus.
Society for Neuroscience Abstracts, 1997.
18. Chen, P.S., Houghton, A.K., Al-Chaer, E.D.,
Westlund, K.N. and Willis, W.D. Responses of primate STT cells
and rat dorsal horn cells to noxious cutaneous mechanical and
thermal stimulation are inhibited by chemical stimulation of the
anterior pretectal nucleus. Society for Neuroscience Abstracts,
1997.
19. Al-Chaer, E.D., Feng, Y., Westlund, K.N. and
Willis, W.D. Visceral pain in the primate: a pathway in the
dorsal column. Gulf Coast GI Research Forum, 1997.
20. Al-Chaer, E.D., Feng, Y., Wei, J., Gondesen,
K., Willis, W.D. and Quast M. Brain activity during noxious
visceral stimulation. Experimental Biology 1998 (FASEB).
21. Quast, M.J., Al-Chaer, E.D., Wei, J., Feng,
Y., Illangasekare, N., Gonzalez, J.M., Deyo, D., Sell, S.,
Gondesen, K.J. and Willis, W.D. High resolution fMRI in a
monkey model of visceral pain. International Society for
Magnetic Resonance in Medicine, 1998.
22. Al-Chaer, E.D. and Willis, W.D. Peripheral
muscarinic receptors: a role in neuronal sensitization
associated with colon inflammation. American Pain Society
Abstracts, 1998.
23. Al-Chaer, E.D., Quast M., Feng, Y., Wei, J.,
Gondesen, K. Illangasekare, N., Deyo, D. and Willis, W.D.
Visceral pain: an asymmetric function of the brain? Neurosci.
Abstr. 24, p. 1389, 1998.
24. Al-Chaer, E.D., Feng, Y. and Willis, W.D.
Quantitative basis for the dorsal column dominant role in
visceral pain in the primate. Digestive Diseases Week Abstract,
p A-900, 1998.
25. Winston, J., Shenoy, M., Micci, M.A., Toma, H.,
Al-Chaer, E.D., Hellmich, Embesi, H. J. and Pasricha,
P.J. Tumor necrosis factor-a
sensitizes primary neonatal sensory neurons in culture: the
potential role of NF-kB
in nociception. Gastroenterology 116 (4): G2854.
26. Al-Chaer, Elie D. and Pasricha, P.J. Transient
colorectal irritation in the neonatal period produces long
lasting visceral sensitization in rats: a potential model for
IBS and other painful functional bowel disorders.
Gastroenterology 116 (4): G4139.
27. Lu, C.L., Winston, J., Shenoy, M., Hellmich, H.,
Al-Chaer, Elie D., Saban, R., Saban, M., Lai, C.R. and
Pasricha, P. J. Changes in neurotransmitter levels and gene
expression after noxious mechanical stimulation of the rectum.
Gastroenterology 116 (4): G4486.
28.
Al-Chaer, E.D., Quast M., Feng, Y., Wei, J.,
Gondesen and Willis, W.D. Brain imaging of the long term
effect of a midline myelotomy on the processing of visceral and
somatic pain using fMRI. Ninth World Congress on Pain,
Abstracts, p. 391, IASP Press, Vienna, Austria 1999.
29. Pasricha, P.J. and Al-Chaer, E.D. Neonatal
colon irritation produces long lasting visceral hyperalgesia: a
potential model for IBS in rats. Ninth World Congress on Pain,
Abstracts, p. 392, IASP Press, Vienna, Austria 1999.
30. Saab, C.Y., Makki, A. A., Quast, M. J., Wei, J.,
Al-Chaer, E. D. and Willis, W. D. Is the cerebellum
involved in pain? Ninth World Congress on Pain, Abstracts, p.
174, IASP Press, Vienna, Austria 1999.
31. Al-Chaer, E.D. and Pasricha, P.J. Recurring
visceral hyperalgesia is mediated by a dynamic neural exchange
along a dorsal horn – thalamus sensitized axis: a new model of
IBS in rats. Society for Neuroscience, 29th Annual
Meeting, Ft. Lauderdale, FL. Abstracts, p. 400, 1999.
32. Saab, C., Makki, A., Quast, M. J., Wei, J., Al-Chaer,
E. D. and Willis, W. D. What might be the implications
of pain processing by the cerebellum? Society for Neuroscience,
29th Annual Meeting, Ft. Lauderdale, FL. Abstracts,
p. 145, 1999.
33. Zhang, H.Q., Al-Chaer, E.D., W.D. Willis and
Chen, P.S. Electrophysiological evidence for referred pain in
colorectal distension in rat. Society for Neuroscience, 29th
Annual Meeting, Ft. Lauderdale, FL. Abstracts, p. 145, 1999.
34. Al-Chaer, Elie D. and Pasricha, P.J. A new
animal model for chronic visceral hyperalgesia in rats. American
Pain Society, 18th Annual Scientific Meeting, Program
Book, p. 187, 1999.
35. Zhang, H.Q., W.D. Willis and Al-Chaer, E.D.
Interactions between vibrotactile skin stimulation and
colorectal pain. American Pain Society, 18th Annual
Scientific Meeting, Program Book, p. 165, 1999.
36. Saab C.Y., Quast M.J., Wei J.N., Makki A., Al-Chaer
E.D. and Willis W.D. Cerebellar activation induced by
peripheral injection of capsaicin: a f-MRI / electrophysiology
study. International Society for Magnetic Resonance in
Medicine (ISMRM), Pennsylvania, May, 1999.
37. Kawasaki M., Pasricha, P.J. and Al-Chaer, E.D.
Blockade of NK1 receptors in the spinal cord reduces the
hypersensitivity associated with colorectal distension in an
animal model of the irritable bowel syndrome. Gastroenterology
118 (4) #4418, 2000.
38. Broussard, R.F., Kawasaki M. and Al-Chaer, E.D.
The dorsal column of the spinal cord facilitates spinal
neuronal sensitization associated with colorectal
hypersensitivity in an animal model of the irritable bowel
sydrome. Gastroenterology 118 (4) #5355, 2000.
39. Pasricha, P.J., Kawasaki M. and Al-Chaer, E.D.
Evidence of central neuronal sensitization associated with
colorectal hypersensitivity in an animal model of the irritable
bowel sydrome. Gastroenterology 118 (4) #5480, 2000.
40.
Al-Chaer, E.D.,
Pasricha, P.J. and Kawasaki M. Evidence of central neuronal
sensitization associated with chronic visceral hypersensitivity
residual to neonatal colon irritation in rats. Federation of
European Neuroscience Societies, 2000.
41. Saab, C.Y.,
Kawasaki M., Masaad, C.A., Saadé, N.E., Al-Chaer, E.D.
and Willis W.D. Is the cerebellum involved in analgesia or Pain?
Society for Neuroscience, 2000.
42. Saab C.Y., Kawasaki M, Al-Chaer E.D. and
Willis W.D. Cerebellar modulation of spinal nociceptive
responses: Can pain be influenced from the cerebellum?
American Pain society, 19th Annual Scientific Meeting,
Atlanta, Georgia, November 2-5, 2000.
43. Al-Chaer, E.D., M. Kawasaki and R.F.
Broussard. Does the dorsal column control access of visceral
information to other sensory channels in the spinal cord?
Society for Neuroscience, 2000.
44. Kawasaki M., Ushida, T. and Al-Chaer, E.D.
Intradermal capsaicin attenuates responses of spinal cord
neurons to colorectal distension: characteristics of
viscerosomatic convergence or DNICs? Society for Neuroscience,
2000.
45. Al-Chaer, E.D. and M. Kawasaki. Rekindling of
neuronal sensitization in the spinal cord by the dorsal column
in an animal model of chronic visceral pain. American Pain
Society, 2000.
46. Al-Chaer, E.D. and Y. Park. Sensitization of
electromyographic responses in an animal model of chronic
visceral hypersensitivity.
Society for Neuroscience, 2001.
47. Park, Y. and Al-Chaer, E.D. Thoracolumbar
neuronal sensitization in an animal model of chronic visceral
hypersensitivity. Society for Neuroscience, 2001.
48. Park, Y. and Al-Chaer, E.D. Thalamic
stimulation differentially modifies spinal neuronal responses to
colorectal distension in rats with chronic visceral pain. The
Journal of Pain 3(2) Supp.1: page 31, #722. American Pain
Society, 2002.
49. Lin, C. and Al-Chaer, E.D. Primary afferent
sensitization in an animal model of chronic visceral pain. The
Journal of Pain 3(2) Supp.1: page 27, #706. American Pain
Society, 2002.
50. Ma, H., Park, Y. and Al-Chaer, E.D.
Functional outcomes of neonatal colon pain measured in adult
rats. The Journal of Pain 3(2) Supp.1: page 27, #707. American
Pain Society, 2002.
51. Park, Y. and Al-Chaer, E.D. Thoracolumbar
neuronal sensitization to colon stimuli in Al-Chaer's animal
model of chronic visceral pain. The Journal of Pain 3(2) Supp.1:
page 27, #708. American Pain Society, 2002.
52. Lin, C. and Al-Chaer, E.D. Exploratory
activity in female rats with neonatal colon irritation varies
with the estrus cycle. International Association for the Study
of Pain (IASP): August 2002, San Diego, CA.
53. Lin, C. and Al-Chaer, E.D. Sensitization of
thoracolumbar primary afferent responses to colorectal
distension (CRD) in an animal model of chronic visceral pain.
Program No. 451.10. 2002 Abstract Viewer/Itinerary Planner.
Washington, DC: Society for Neuroscience, 2002. CD-ROM.
54. Hinze, C.L.,
Lin C. and Al-Chaer, E.D. Estrous cycle and
stress related variations of open field activity in adult female
rats with neonatal colon irritation (CI). Program No. 155.14.
2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society
for Neuroscience, 2002. CD-ROM.
55. Al-Chaer, E.D. and Lin, C. Sex-related
differences in exploratory activity in adult rats exposed to
neonatal colon pain. Program No. 482.8. 2003 Abstract
Viewer/Itinerary Planner. Washington, DC: Society for
Neuroscience, 2003. CD-ROM.
56. Lin, C. and Al-Chaer, E.D. Differential
effects of NMDA and non-NMDA receptor antagonists on
visceroceptive dorsal horn neurons in adult rats exposed to
neonatal colon pain. Program No. 482.9. 2003 Abstract
Viewer/Itinerary Planner. Washington, DC: Society for
Neuroscience, 2003. CD-ROM.
57. Al-Chaer, E.D. and Park, Y-C. Sensitization of
spinal thoracolumbar neurons to colon stimuli in adult rats
exposed to neonatal colon pain. DDW, W1429, Gastroenterology
2003.
58. Wang, J., Peng, Xin and Al-Chaer, E.D.
Sex-related differences in visceral sensitivity in adult rats
with neonatal colon pain. Gastroenterology 126 (4)
(Suppl. 2): A-161 (S1090), 2004.
59. Wang, J., Xie J. and Al-Chaer, E.D. Plastic
changes in the role of N-methyl-D-aspartate (NMDA) receptors in
the behavioral responses to colorectal distension (CRD) in adult
rats exposed to neonatal colon irritation (CI).
Gastroenterology 126 (4) (Suppl. 2): A-161 (S1091), 2004.
60. Xie, J., Song, R.H., Wang, J., and Al-Chaer, E.D.
Up-regulation of NR1 subunit of N-methyl-D-aspartate (NMDA)
receptors in adult rats with neonatal colon irritation and
behavioral implications. Gastroenterology 126 (4) (Suppl.
2): A-161 (S1103), 2004.
61. J. Wang,
E.D. Al-Chaer.
Role of N-methyl-D-aspartate (NMDA) receptors in sensitization
of A - and
C- primary afferent fibers to colorectal distension (CRD) in
adult rats exposed to neonatal colon irritation (CI) Program No.
172.10. 2004 Abstract Viewer/Itinerary Planner.
Washington, DC: Society for Neuroscience, 2004.
62. J. Xie, J. Wang,
E.D. Al-Chaer.
Role of N-methyl-D-aspartate (NMDA) receptors in the visceral
hypersensitivity of adult rats exposed to neonatal colon
irritation (CI). Program No. 172.11. 2004 Abstract
Viewer/Itinerary Planner. Washington, DC: Society for
Neuroscience, 2004.
63. R.H. Song, J. Xie, J. Wang,
E.D. Al-Chaer.
Differential regulation of NR1 subunit of N-methyl-D-aspartate (NMDA)
receptor in the spinal cord (SC) and dorsal root ganglia (DRG)
of adult rats exposed to neonatal colon pain and behavioral
implications. Program No. 172.12. 2004 Abstract
Viewer/Itinerary Planner. Washington, DC: Society for
Neuroscience, 2004.
64. X. Peng, J. Wang,
E.D. Al-Chaer.
Sex-related differences in visceral sensitivity in adult rats
with neonatal colon pain Program No. 172.13. 2004 Abstract
Viewer/Itinerary Planner. Washington, DC: Society for
Neuroscience, 2004.
65. Jing Wang, Chunping Gu, Xin Peng, Kirsten Garner and
Elie D. Al-Chaer.
Estrogen modulates visceral sensitivity in rats. Program No.
52.7, 2005 Abstract Viewer/Itinerary Planner. Washington,
DC: Society for Neuroscience, 2005.
66. Chunping Gu, Jing Wang, Xin Peng, Kirsten Garner, Cheng Wang
and
Elie D. Al-Chaer.
Nenonatal colon irritation induces alterations in mRNA and
protein expression of NMDA receptor NR1 subunit in rats. Program
No. 52.8, 2005 Abstract Viewer/Itinerary Planner.
Washington, DC: Society for Neuroscience, 2005.
67. Jing Wang, Chunping Gu, Xin Peng, Kirsten Garner and
Elie D. Al-Chaer.
Estrogen modulates visceral sensitivity in adult rats exposed to
neonatal colon irritation (CI). DDW 2006. Gastroenterology
130 (4) S2: S1749, p. A-249, 2006.
68. Jing Wang, Kirsten Garner and
Elie D. Al-Chaer.
Gonadal hormones modulate stress-induced visceral
hypersensitivity in rats. DDW 2006. Gastroenterology 130
(4) S2: S1773, p. A-254, 2006.
69. C. Gu, J. Wang,
E. D. Al-Chaer.
Neonatal intracolonic zymosan: a new model of post-inflammatory
chronic visceral hypersensitivity in adult rats. Program No.
142.14. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society
for Neuroscience, 2006.
70. J. Wang, C. Gu, C. Y. Saab,
E. D. Al-Chaer.
Glial cells: a newly-discovered role in visceral
hypersensitivity? Program No. 142.15. 2006 Neuroscience Meeting
Planner. Atlanta, GA: Society for Neuroscience, 2006.
71. Jing Wang, Kirsten Garner, Chunping Gu, Carl Y. Saab, and
E. D. Al-Chaer.
Glial cells: a newly-discovered role in visceral
hypersensitivity? DDW 2007, Gastroenterology 132 (4) S2:
T2001, p. A-600, 2007.
72.
E. D. Al-Chaer,
C. Gu, A. Hayar.
An improved method for patch clamp recording of neurons in the
intact dorsal root ganglion (DRG) in rats. Program No. 725.16.
2007 Neuroscience Meeting Planner. San Diego, CA: Society for
Neuroscience, 2007.
73. J. Wang,
E.D. Al-Chaer.
Sex hormones modulate primary afferent responses to colorectal
distension (CRD) in rats. Program No. 725.15. 2007 Neuroscience
Meeting Planner. San Diego, CA: Society for Neuroscience, 2007.
74.
Al-Chaer E.D.,
Gu C., Soni P., Garner K.N., Fann A., Wang J. Neonatal Cuddling
Prevents the Development of Adverse Consequences of Neonatal
Injury in Rats. Pediatric Academic Societies Meeting, Honolulu,
Hawaii, #4454.14, 2008.
75. Archana Rao,
Elie D. Al-Chaer,
and Beverley Greenwood-Van Meerveld. Repetitive Colorectal
Distension in Neonatal Rats Induces Colonic Mucosal and Muscular
Dysfunction in Adulthood. Abstract #807, Digestive Disease Week,
San Diego 2008
76. Jing Wang, Chunping Gu, and
Elie D. Al-Chaer.
Sex Differences in the Characteristics and Role of the
Postsynaptic Dorsal Column (PSDC) Pathway in Visceral Pain.
Abstract #T1434, Digestive Disease Week, San Diego 2008.
77.
Al-Chaer E.D.,
Gu C. and Wang J. Sex Differences in the Characteristics and
Role of Visceral Pain Pathways. Presentation Number: PM 312, 12th
World Congress on Pain, Glasgow, UK, 2008.
78. C Gu, J Wang, P Soni, KN Garner,
E.D. Al-Chaer.
Neonatal cuddling prevents the development of adverse
consequences of neonatal injury in rats via opiate and CRF
sensitive pathways. Program No. 171.11/LL12. 2008 Neuroscience
Meeting Planner. Washington, DC: Society for Neuroscience, 2008.
Online.
79. J Wang, C Gu,
E.D. Al-Chaer.
Sex hormones modulate the role of the postsynaptic dorsal column
(PSDC) pathway in visceral pain. Program No. 171.14/LL15. 2008
Neuroscience Meeting Planner. Washington, DC: Society for
Neuroscience, 2008. Online.
80. Jing Wang, Krishnapraveen Yadlapalli, John E. Donello,
Daniel W. Gil,
Elie D. Al-Chaer.
Role of the Sympathetic Nervous System in Chronic Visceral
Hypersensitivity in Rats. Abstract #109, Digestive Disease Week,
Chicago 2009.
81.
M. Dobretsov, D. Romanovsky,
E.D. Al-Chaer.
Pressure-induced pain: early sign of diabetes-associated
impairment of insulin production in rats. Program#: 435.2, 2009
Neuroscience Meeting Planner. Chicago, IL: Society for
Neuroscience, 2009.
82. M.R. Watts, J. Watts, C. Gu and
E.D. Al-Chaer.
The effect of 2,4,6-trinitrobenzenesulphonic (TNBS) acid-induced
colon inflammation on the activation state of microglia in L6-S1
segments of the rat spinal cord. Program#: 655.25, 2009
Neuroscience Meeting Planner. Chicago, IL: Society for
Neuroscience, 2009.
83. J. Wang, C.Y. Saab and
E.D. Al-Chaer.
P2X and p38 MAPK activate spinal cord microglia in rats with
visceral hypersensitivity. Program#: 655.26, 2009 Neuroscience
Meeting Planner. Chicago, IL: Society for Neuroscience, 2009.
84. J.L. Watts and
E.D. Al-Chaer.
The effect of ibuprofen and morphine on visceral
hypersensitivity in rats with 2,4,6-trinitrobenzenesulphonic (TNBS)
acid-induced colon inflammation. Program#: 655.27, 2009
Neuroscience Meeting Planner. Chicago, IL: Society for
Neuroscience, 2009.
85. C. Gu, J. Watts and
E.D. Al-Chaer.
Effect of neonatal colon inflammation on the activation state of
microglia in the adult rat spinal cord. Program#: 655.28, 2009
Neuroscience Meeting Planner. Chicago, IL: Society for
Neuroscience, 2009.
86. Daniel W. Gil, Jing Wang, Chunping Gu, John E. Donello,
Elie D. Al-Chaer.
Selective effect of alpha2-adrenergic agonist, AGN-203818, on
chronic visceral hypersensitivity in rats. Presentation #939,
Digestive Disease Week, New Orleans, LA, 2010.
87. J.L. Watts, C. Gu, C.Y. Saab,
E.D. Al-Chaer.
The effect of minocycline on the activation state of microglia
in the spinal cord of rats with colon inflammation induced by
2,4,6-trinitrobenzenesulphonic (TNBS) acid. Program#: 682.15,
2010 Neuroscience Meeting Planner. San Diego, CA: Society for
Neuroscience, 2010.
88.
E.D. Al-Chaer
and J.L. Watts. P2Y12 receptor mRNA expression is decreased in
rats with 2,4,6-trinitrobenzenesulfonic (TNBS) acid - induced
colon inflammation. Program#: 682.20, 2010 Neuroscience Meeting
Planner. San Diego, CA: Society for Neuroscience, 2010.
89. B.W. LeBlanc, M. Iwata, Q.-G. Nguyen, A.C.G. Crego, J.L.
Watts,
E.D. Al-Chaer,
C.Y. Saab. Hyperactive microglia and central sensitization in a
model of colon inflammation. Program#: 682.21, 2010 Neuroscience
Meeting Planner. San Diego, CA: Society for Neuroscience, 2010.
90. M.R. Watts and
E.D. Al-Chaer.
Activation of α2-adrenoceptors alleviates visceral
hypersensitivity in an animal model of colon inflammation.
Program#: 682.22, 2010 Neuroscience Meeting Planner. San Diego,
CA: Society for Neuroscience, 2010.
91. J. Wang, C. Gu, S. Cabrera, J. Donello, D. Gil and E.D.
Al-Chaer. Is chronic visceral hypersensitivity a
sympathetically-mediated pain? Program#: 682.23, 2010
Neuroscience Meeting Planner. San Diego, CA: Society for
Neuroscience, 2010.
92. C. Gu, J. Wang, J.L. Watts, C.Y. Saab and
E.D. Al-Chaer.
p38 MAPK inhibitor ameliorates chronic visceral hypersensitivity
in rats with neonatal colon irritation. Program#: 682.24, 2010
Neuroscience Meeting Planner. San Diego, CA: Society for
Neuroscience, 2010.
94. K. Yadlapalli, A.M. Hayar and
E.D. Al-Chaer.
Differential effects of ATP on the electrophysiological
properties of dorsal horn neurons in the rat. Program#: 682.25,
2010 Neuroscience Meeting Planner. San Diego, CA: Society for
Neuroscience, 2010.
Manuscripts in Preparation
A. Book Chapters
1. Elie D. Al-Chaer. The neuroanatomy of pain and
pain pathways. In “Handbook of Pain and Palliative Care:
Biobehavioral Approaches for the Life Course”, Rhonda J.
Moore, Editor, Springer.
B. Original Scientific Articles
1. Wang, J., Peng, X., and Al-Chaer, E.D. Role of
N-methyl-D-aspartate (NMDA) receptors in the visceral
hypersensitivity to colorectal distension (CRD) in adult rats
exposed to neonatal colon irritation (CI).
2. Wang, J., Gu C. and Al-Chaer, E.D. Sex
differences in the role of the postsynaptic dorsal column in
visceral pain.
Recreation
You can build your mind, you can build your body and you can
build your CV.
[I said that]
Besides a few visits to the gym every now and then, a game of
tennis when a partner is available or a hike to the nearest
trail when the weather permits, I am not much of a body builder.
So, when I am not engaged in activities that build my CV, I
immerse myself in problems of geometry, philosophy, knowledge
and existence; “mental gymnastics.” The mathematician in me
likes to draw logical deductions that the philosopher likes to
challenge. The geometrician likes to draw lines and to sketch
plans in an attempt to realize a nagging idea or give shape to a
fleeting dream. The strategist often calls for another game of
chess. At the end of the day (or the night), I find myself with
an idiosyncratic house plan, a highly critical opinion written
in a blog on a website of my design, or on my knees praying for
a revelation that will bring me closer to the Truth.
Having said all that, I find the most rewarding activity to be
the play-time and quality-time that I spend with my son. Seeing
the world through the fresh eyes of an eight year old never fails
to give me a renewed perspective on life.
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